What happens if you are unable to process my sample?

In rare cases, it's not possible to generate a 3X4 report from a provided sample. This can happen despite multiple processing attempts, and is the result of biological or technical factors — not a problem with how the sample was collected.

Why DNA sample processing can fail

DNA sequencing is a physical process that relies on molecular probes binding to specific regions of genetic material. For some individuals, the natural structure or composition of their DNA makes it harder for these probes to bind effectively. When binding is insufficient, the genotyping instruments can't read the genetic data with the accuracy required to produce a report.

This is a known limitation of current genomic technology and is primarily influenced by individual genetic variation — it is not typically a reflection of sample quality.

What about DNA extraction failure?

Before sequencing begins, the lab must first extract usable DNA from the sample. In some cases, a sample won't pass this initial step because the DNA quantity or quality is too low for testing. This can happen when organic compounds — such as carbohydrates, phenolic acids, or substances from food, drinks, makeup, or tobacco — are present in the sample.

Following the sample collection instructions carefully is the best way to avoid this.

How many attempts will be made?

While most samples yield usable data on the first attempt, the lab and quality control teams will make up to three attempts in total. This may include reprocessing the original sample or requesting a new sample collection if needed.

What happens if my DNA sample still fails?

If a report cannot be generated after three attempts, a full refund will be issued.

How can I avoid a failed sample?

Follow the sample collection instructions provided after you register your kit. These are your most important tool for a successful result.

If you need help accessing the instructions, contact us at orders@3X4genetics.com.